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Scientists have begun to discover that numerous genes play a role in cancer, but they have only uncovered a small portion of these genes. The Cancer Genome Atlas is aimed at helping to accelerate the understanding of the genetic make-up of cancer. Researchers hope that a better understanding of how cancer develops and spreads, will lead to new tests to detect cancer in its early, most treatable stages; new therapies to target cancer; and, ultimately, new strategies to prevent cancer. Understanding of the genetic basis for cancer has already allowed researchers to develop the first drugs that target faulty genes, which viagra cialis levitra in Moorhead making a difference in the lives of patients.

Just ask Bob Ferber. In July of 1999, the Los Angeles attorney was diagnosed with Philadelphia chromosome-positive Ph chronic myeloid leukemia CML, a malignant cancer of the bone marrow and blood. Ferber tried many futile attempts at treatment before entering a clinical trial for a drug now called Gleevec imatinib mesylate tablets to help fight his disease. Gleevec, approved by the FDA in 2001, is one of the first "targeted therapies" and works by turning off the specific cause of Ph CML, something The Cancer Genome Atlas hopes to make possible for many more cancers. Within months, Ferbers white blood cell counts were within normal range and his disease viagra cialis levitra in Moorhead in remission. "My CML diagnosis was a real scare. But, Im grateful now. Im grateful for every new day I have. " Sadly, not everyones story is as positive as Ferbers. Hopefully, with the continued advancement of cancer awareness and research, preventative treatment and The Cancer Genome Atlas, cancer patients will one day be able to breathe a sigh of relief and agree with Ferber when he says, "Every time I challenge this cancer, emotionally or physically-and survive-thats a victory for me.

" Researchers have developed the first cancer-fighting drugs that target faulty genes. Note to Editors About Gleevec Tablets Gleevec imatinib mesylate tablets are indicated for the treatment of newly diagnosed adult patients with Philadelphia chromosomeand8722;positive Ph chronic myeloid leukemia CML in chronic phase. Follow-up is limited. Gleevec tablets are also indicated for the treatment of patients with Ph CML in blast crisis, in accelerated phase or in chronic phase after buy viagra cialis levitra in Moorhead online of interferon-alpha IFN-a therapy. Important Safety Information1 Severe NCI Grades 34 neutropenia 3and8722;48, anemia 1and8722;42, thrombocytopenia 1and8722;33, hemorrhage 1and8722;19, fluid retention 1and8722;8 eg, pleural effusion, pulmonary edema, and ascites and superficial edema 1and8722;6, musculoskeletal pain 1and8722;9, and hepatotoxicity 3and8722;8 were reported among Gleevec recipients. Patients should be weighed and monitored regularly for signs and symptoms of edema, which can be serious or life-threatening.

There have also been reports, including fatalities, of cardiac tamponade, cerebral edema, increased intracranial pressure, papilledema, and gastrointestinal perforation. Bullous dermatologic reactions eg, erythema multiforme and Stevens-Johnson syndrome have also been reported. In some cases, the reaction recurred upon rechallenge. Several foreign postmarketing cases note a resolution or improvement of bullous reaction following dose reduction with or without supportive care. Dose adjustments may be necessary due to hepatotoxicity, other nonhematologic adverse events, or hematologic adverse events. Therapy with Gleevec was discontinued for adverse events in 3 to 5 of patients. Patients with severe hepatic impairment should be treated at a starting dose of 300mgday and should be closely monitored.

Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Gleevec Tablets should increase by at least 50 and clinical response should be carefully monitored in patients receiving Gleevec Tablets with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include acetaminophen, warfarin, erythromycin, and phenytoin. Please see enclosed full prescribing information for other potential drug interactions. For daily dosing of 800mg and above, dosing should be accomplished using the 400mg tablets to reduce exposure to iron. Use of Gleevec Tablets is contraindicated in patients with hypersensitivity to imatinib or to any other component of Gleevec Tablets. Women of childbearing potential should be advised to avoid becoming pregnant while taking Gleevec Tablets.

Because of the potential for serious adverse reactions in nursing infants, women should be advised to avoid breast-feeding while taking Gleevec Tablets. Common Side Effects of Gleevec Tablets1 The majority of the approximately 1700 adult patients who received Gleevec in clinical studies experienced adverse events at some time, but most were mild to moderate in severity. The most frequently reported adverse events were superficial edema 58and8722;81, nausea 47and8722;74, diarrhea 39and8722;70, muscle cramps 28and8722;62, vomiting 21and8722;58, rash 36and8722;53, fatigue 30and8722;53, musculoskeletal pain 30and8722;49, and abdominal pain 30and8722;40. Supportive care may help management of most mild-to-moderate adverse events so that prescribed dose can be maintained whenever possible. Gleevec tablets should be taken with food and a large glass of water to minimize gastrointestinal GI irritation.

Gleevec tablets should not be taken with grapefruit juice. 1 Gleevec imatinib mesylate tablets prescribing information. East Hanover, NJ Novartis Pharmaceuticals Corporation; 2005. Numbers indicate the range of percentages in 4 studies among adult patients with Ph CML in blast crisis, accelerated phase, and chronic phase. Cancer Update Non-Hodgkins Lymphoma Treatment Options This makes it very important for patients, their caretakers and their loved ones to talk to a physician about all available treatment options and to get access to the latest therapies. Non-Hodgkins lymphoma NHL, a cancer affecting the lymphatic system, is the second-fastest-rising cancer in the United States.


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